Led by Dr Chiara de Lucia
Anthocyanins are dietary flavonoids with strong anti-oxidant capacities, mostly found in dark berries and fruits. ACID is a 24-week intervention during which older individuals (60+) at risk for dementia are given capsules containing purified anthocyanins or placebos. The main study aim is to assess the potential of these supplements in delaying cognitive decline.
Thoroughout the trial we have collected a wide range of biomarkers to establish how anthocyanins infer their protective effects. Most notably, longitudinal cerebrospinal fluid and blood sample collection allowed for repeat measurements of circulating ACN metabolites. Alongside this, analyses aimed at delineating the trial’s effects on neuroimaging paramerers, the gut microbiome, blood and CSF inflammation and blood lipid and metabolite profiles are also currently ongoing.
Blood-derived serum was also collected at baseline and endpoint and is being used to carry out the Thuret lab’s in vitro parabiosis assay. This will help us establish wether anthocyanin suplementatio alters the neurogenic process.
This project is led by postdoctoral research fellow Dr. de Lucia who is funded by a Helse Vest fellowship.
Thuret Lab 