Mechanisms underlying the role of gut-microbiota in exercise-induced changes in cognitive function in middle-age

Led by Dr Curie Kim

This project will decipher the dialogue between the brain, the gut microbiota and exercise by investigating the impact of a 12-week online exercise intervention in healthy middle-aged community-dwelling adults who do not habitually exercise on global cognition, hippocampus-dependent cognition, mood, quality of life and brain-derived neurotrophic factor.

Serum samples will be used in our in vitro parabiosis assay to gain insights into the corresponding impact on the neurogenic process. Whilst stool samples will be collected for our collaborators at University College Cork to elucidate the impact on the gut microbiota and metabolomic profile.