Led by Zarah Haniff
This project will investigate the impact of psilocybin, a psychedelic compound capable of alleviating symptoms of depression, on adult hippocampal neurogenesis and microglial polarisation.
Human cellular models involving hippocampal and microglial stem cell lines will be used to determine mechanisms underlying mood and cognitive function changes in depressed patients.
An ongoing RCT led by Dr James Rucker and Prof. Allan Young, will assess the efficacy of psilocybin-assisted therapy for treatment-resistant major depressive disorder (PsiDeR).
Serum from trial participants will be applied to the in vitro parabiosis assay developed by the Thuret Lab to establish changes in neurogenic markers, as a proxy biomarker for neurogenesis.
This project is led by PhD-student Zarah Haniff.
Thuret Lab 