The central theme of the lab is adult hippocampal neurogenesis – which is implicated in memory formation and mood regulation.
We investigate environmental and molecular mechanisms controlling the production of these adult-born neurons and how they impact mental health.
We study neurogenesis in healthy ageing as well as in the context of diseases such as Alzheimer’s and depression.
By approaching neurogenesis in health and disease, the strategy is two folds:
- Validating the neurogenic process as a target for prevention and pharmacological interventions.
- Developing neurogenesis as a biomarker of disease prediction and progression.
You can grow new brain cells. Here’s how | Sandrine Thuret | TED
Ongoing projects
Dr Curie Kim
Mechanisms underlying the role of gut-microbiota in exercise-induced changes in cognitive function in middle-age
Dr Edina Silajdžić
Developing and validating a biomarker assay using neural stem cells in vitro to predict and follow Alzheimer’s disease progression
Sahand Farmand
Investigating the impact of exercise on neural stem cells and cognition: uncovering molecular mechanisms and exercise mimetic drugs
Dr Chiara de Lucia
ACID: a randomised controlled clinical trial investigating the role of purified anthocyanins in older adults at risk for dementia
Zarah Haniff
Psilocybin on mood and cognitive function mediated by hippocampal neurogenesis and microglia in patients with major depressive disorder
Gargi Mandal
Determining whether hippocampal neurogenesis can predict antidepressant response in Major depressive disorder
Thuret Lab 